????? ???????????. ??? ????????? ????? ?? ?????? ? ?????????? ??????, ? ??????, ? ????????? (??????????? ? ????? allrefer.com).
????????????? ?? ??????????? ????? ???????? (Harvard Medical School), ???????????? ???????? ???????????? ???????? (Weill Cornell Medical College) ? ????????????? ????????? ??????????????? ??? (National Institutes of Health) ????????? ?? ???????? ? ??????? ????????????? ???? ?????, ??????? ???????? ?? ?????????? ??????.
??? 70 ??? ?????? ??????, ?????? ?? ????? ?? ????????????????? ????? ????????. ???? ????????, ??? ????????? ?????????? ? ??????? ???? ????? ?????. ????? ?????? ????????, ??? ??????? ??? ?? ?? ?????? ????. ? ????? ??? ????? ??? ????????? ????? ? ??????-???????. ? ???, ???????, ??????? ????? ? ?? ????????.
????? ?????? ???????????? ????????? ???????? (??????????? ?????????? ??????????? ??????? – ???? ??????), ???? ????????? Sirtuin ???????????? ???????????????? ????????? ? ????? ?????????, ? ????? ?????????????? ????????.
???? ?? ????? ????? SIRT1 ??? ?????????? ??????? ???????, ? ? ??????? ???? ??????? ????????? (David Sinclair) ???? ???????? ??? ??????? ?? ????????????????? ?????, ????????????? ????????????? (resveratrol ????????, ?????????????? ? ??????? ????).
?????? ????? ? ?????????????? ? ?????? ????? (Anthony Sauve) ? ???????? ?? ???? (Rafael de Cabo) ??????? ????????, ??? ??? ??? ???? (SIRT3 ? SIRT4) ?????? ?? ??, ??????? ???????? ??????.
??????, ?? ?????? SIRT3 ? SIRT4 ??????? ????????????????? ????? ??????????? ("?????????????? ???????" ??????), ??????? ?????????? ??????? ??? ??????????? ???????? ? ??????????.
????? ?????? ?????????? ?????????? ??????????? ?????, ?????????????? ??? NAMPT, ??????? ????? ??????? ????????????? ??????? (????????, NAD) ? ???????????? ?????????? ????? ?????, ? ????? ??????, ???????? ?????????? SIRT3 ? SIRT4. ??? ? ???? ??????? ?????????? ?????? ???????? ???????????? ????????, ??????????? ??? ????? "????????" ???????????. ?????????? ???????????? ?? ??????? ??????????, ??????? ???????? ?????? ??????????? (??? ?????????, ??? ?? ????? ??????? ??????????? ?? ????? ?????????? ??????????).
"???? ??? ??????? ?????-?? ??????? ???????????? ??????? ?????? NAD ? ??????, ?? ?? ?????? ????????????? ?????? SIRT3 ? SIRT4. ?????? ? ??? ???? ??? ????????? ??????? ??? ??? ???? ??????, ?? ??????? ????? ?????????????? ????????? ??? ?????? ? ????????? ????????", ????????? ?????, ??????? ????? ???????? ??????????? ? ?????? ?????? ?????????? ???????? Sirtris Pharmaceuticals. ????????, ??? ?????? ???????????? ????? ????????? "?? ????????", ????????? ????? ?????? ??? ??????? ???? ? ???????.
?? ??? ?????? ????? ????????????: ?????? ????????? ????? ????? ???? 2-???????? ?????????. ? ????????? ??????, ???, ????????, ???????? ????? (Fr?d?ric Picard) ?? ???????????? ?????? ? ??????? (l'Universit? Laval, Qu?bec), ??????? ????? ???? ?????????????.
"? ?? ????? ??????????? ?? ???????????? ? ?????? ????? ?? ?????????, ??????????? ? ??? ???-????? ???? (Shin-ichiro Imai) ?? ???????????? ?????????? ? ????-????? (Washington University in St. Louis), ??????? ?? ?????? ????? ????? ? ???????? ????????, ?? ?????? ?????? ??????? ?????????? ????? ?????????? ?????? ?????????".
??????????? ???????? ?? ?????? ?????? ?? ?????? ???????, ?????????????? ? ??????? Cell. ???????? ????? ????? ? ???????? ??????? ???????? ?????.